SLC26A11

Across TCGA patient cohorts, SLC26A11 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC26A11-associated genes across cancer lineages are ATM, MEK1, and Shc_pY317. Each is linked with SLC26A11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC26A11-to-partner and partner-to-SLC26A11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC26A11-low versus SLC26A11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC26A11→partner) and Y-score (partner→SLC26A11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.575	-3.308	<.001	.009	3	3
UCEC	MEK1 →	+0.500	+3.000	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.163	-2.584	.005	.001	3	2
UCEC	c-Kit →	-0.198	-2.584	.027	.001	3	2
SKCM	PDCD4 →	-0.405	-3.000	.043	.034	3	2
UCEC	A-Raf_pS299 →	-0.125	-2.584	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

ATM by SLC26A11 expression — UCEC

Explore this box plot interactively →