SLC26A11

Across TCGA pan-cancer cohorts, SLC26A11 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SLC26A11 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher SLC26A11 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC26A11 expression acts as an unfavorable survival marker, although some lineages such as PAAD and BRCA show a favorable association.

LIHC, ACC, and UVM are the cancer types where SLC26A11 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.457	0.628	<.001	94	view →
ACC	DFS	Median	All	0.208	0.667	<.001	93	view →
UVM	DFS	Tertile	II,III,IV	0.298	0.746	.002	87	view →
PAAD	DFS	Median	All	0.415	0.189	<.001	71	view →
BRCA	OS	Quartile	III,IV	0.895	0.699	.002	34	view →
HNSC	OS	Tertile	III,IV	0.681	0.540	.008	31	view →
UCEC	DFS	Quartile	All	0.751	0.867	.003	24	view →
LGG	DFS	Tertile	All	0.319	0.507	<.001	23	view →
ESCA	DFS	Quartile	All	0.250	0.450	.005	22	view →
MESO	OS	Tertile	IV	0.318	0.813	.013	15	view →
COAD	DFS	Quartile	All	0.399	0.626	.004	13	view →
SKCM	OS	Tertile	II,III,IV	0.470	0.205	.017	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SLC26A11–LIHC (DFS)

Open the LIHC breakdown →