SLC25A5

Across TCGA pan-cancer cohorts, SLC25A5 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC25A5 data layer compared with 1 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SLC25A5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC25A5 expression acts as an unfavorable survival marker, although some lineages such as KIRC and OV show a favorable association.

ESCA, BRCA, and UVM are the cancer types where SLC25A5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	All	0.414	0.667	<.001	54	view →
BRCA	OS	Median	II,III,IV	0.510	0.618	.002	49	view →
UVM	DFS	Quartile	III,IV	0.169	0.900	<.001	35	view →
HNSC	OS	Tertile	All	0.238	0.624	<.001	35	view →
KIRC	OS	Tertile	All	0.707	0.523	.002	27	view →
LIHC	OS	Quartile	All	0.581	0.781	.001	24	view →
UCS	DFS	Tertile	III,IV	0.281	0.651	.016	16	view →
OV	OS	Quartile	IV	0.594	0.281	.014	16	view →
TGCT	DFS	Median	All	0.759	0.901	.012	8	view →
CESC	OS	Tertile	All	0.698	0.407	.015	8	view →
READ	OS	Quartile	IV	0.439	0.889	.019	7	view →
ACC	OS	Median	IV	0.344	0.724	.038	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC25A5–ESCA (OS)

Open the ESCA breakdown →