SLC25A5

Across TCGA pan-cancer cohorts, SLC25A5 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC25A5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SLC25A5 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC25A5 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, LIHC, and HNSC are the cancer types where SLC25A5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.392	<.001	11	view →
LIHC	All	II,III,IV	+0.896	<.001	9	view →
HNSC	Male	All	+0.741	<.001	8	view →
UCEC	All	III,IV	+1.081	.001	6	view →
KIRP	Male	All	−0.823	<.001	6	view →
BRCA	All	III,IV	+0.818	<.001	6	view →
BLCA	Male	All	+0.599	.002	6	view →
LUSC	Male	All	+0.770	<.001	5	view →
KICH	All	All	+0.714	.003	4	view →
THCA	Male	II,III,IV	−0.411	.005	4	view →
STAD	Female	All	+0.722	.034	3	view →
CHOL	Female	All	+1.333	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC25A5–KIRC

Open the KIRC breakdown →