SLC25A5

Across TCGA pan-cancer cohorts, SLC25A5 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SLC25A5 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SLC25A5 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SLC25A5 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

PDAC, HNSC, and GBM are the cancer types where SLC25A5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	IV	0.381	0.951	.006	15	view →
HNSC	DFS	Median	All	0.698	1.000	.020	8	view →
GBM	DFS	Median	All	0.872	0.654	.023	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SLC25A5–PDAC (OS)

Open the PDAC breakdown →