SLC25A48

Across TCGA patient cohorts, SLC25A48 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A48-associated genes across cancer lineages are JNK_pT183_Y185, Notch1, and p38-MAPK_pT180_Y182. Each is linked with SLC25A48 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A48-to-partner and partner-to-SLC25A48 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SLC25A48-low versus SLC25A48-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A48→partner) and Y-score (partner→SLC25A48) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.198	-3.169	.009	.019	3	1
UCEC	Notch1 →	+0.228	+2.700	<.001	.006	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.482	-1.986	.017	.032	3	1
UCEC	p62 Lck ligand →	+0.327	+3.331	.026	.005	3	1
UCEC	Tuberin →	+0.310	+2.000	.010	.032	3	1
UCEC	Caspase-8 →	-0.287	-3.459	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK_pT183_Y185 by SLC25A48 expression — UCEC

Explore this box plot interactively →