SLC25A48

Across TCGA pan-cancer cohorts, SLC25A48 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC25A48’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SLC25A48 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC25A48 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, THCA, and KIRP are the cancer types where SLC25A48 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A48 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−2.901	<.001	10	view →
THCA	Male	All	+0.731	<.001	10	view →
KIRP	Male	III,IV	−1.668	<.001	8	view →
KIRC	Male	All	−1.070	<.001	7	view →
LUSC	All	II,III,IV	+0.533	<.001	6	view →
HNSC	All	III,IV	+0.350	.008	6	view →
LUAD	Female	All	+0.203	<.001	6	view →
BRCA	All	All	+0.368	.006	4	view →
CHOL	Male	All	−0.135	<.001	4	view →
COAD	All	All	−0.337	.002	3	view →
BLCA	Female	All	+0.066	.025	3	view →
PRAD	All	All	+0.706	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC25A48–KICH

Open the KICH breakdown →