SLC25A44

Across TCGA patient cohorts, SLC25A44 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A44-associated genes across cancer lineages are VHL, ACC_pS79, and Gab2. Each is linked with SLC25A44 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A44-to-partner and partner-to-SLC25A44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by SLC25A44-low versus SLC25A44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A44→partner) and Y-score (partner→SLC25A44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.729	-2.321	.032	.034	3	2
UCEC	ACC_pS79 →	+0.366	+2.321	.035	.035	3	1
UCEC	Gab2 →	+0.441	+3.459	.013	.005	3	1
UCEC	JNK2 →	+0.318	+2.834	.001	.034	3	1
UCEC	NF-kB-p65_pS536 →	+0.485	+3.459	.033	.005	3	1
UCEC	p21 →	+0.243	+2.321	.011	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

VHL by SLC25A44 expression — UCEC

Explore this box plot interactively →