SLC25A44

Across TCGA pan-cancer cohorts, SLC25A44 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated SLC25A44 data layer compared with 2 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher SLC25A44 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC25A44 expression acts as an unfavorable survival marker, although some lineages such as KIRC and PAAD show a favorable association.

ACC, MESO, and KIRC are the cancer types where SLC25A44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.178	0.716	<.001	93	view →
MESO	OS	Median	All	0.288	0.485	.002	73	view →
KIRC	DFS	Median	All	0.707	0.550	<.001	59	view →
KICH	OS	Tertile	II,III,IV	0.548	1.000	.002	54	view →
PAAD	OS	Quartile	All	0.583	0.311	<.001	33	view →
UCEC	DFS	Median	All	0.795	0.874	.007	26	view →
HNSC	DFS	Quartile	IV	0.753	0.543	.003	21	view →
BLCA	DFS	Median	II,III,IV	0.439	0.573	.001	19	view →
ESCA	DFS	Tertile	III,IV	0.271	0.593	.007	16	view →
READ	DFS	Quartile	III,IV	0.337	0.882	.003	16	view →
UVM	DFS	Quartile	All	0.429	0.727	.021	12	view →
KIRP	DFS	Median	IV	0.038	0.527	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

SLC25A44–ACC (DFS)

Open the ACC breakdown →