SLC25A40

Across TCGA patient cohorts, SLC25A40 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A40-associated genes across cancer lineages are Heregulin, Annexin-1, and S6_pS240_S244. Each is linked with SLC25A40 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A40-to-partner and partner-to-SLC25A40 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heregulin grouped by SLC25A40-low versus SLC25A40-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A40→partner) and Y-score (partner→SLC25A40) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Heregulin →	-0.148	-2.321	.017	.035	3	1
UCEC	Annexin-1 →	+0.569	+2.321	.031	.035	3	1
UCEC	S6_pS240_S244 →	+0.549	+2.321	.007	.035	3	1
UCEC	CD49b →	-0.320	-3.150	.025	.019	3	1
UCEC	eIF4G →	+0.322	+2.321	.039	.035	2	1
UCEC	MEK1 →	+0.364	+2.321	.047	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Heregulin by SLC25A40 expression — UCEC

Explore this box plot interactively →