SLC25A40

Across TCGA pan-cancer cohorts, SLC25A40 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated SLC25A40 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLC25A40 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SLC25A40 expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

KIRC, LGG, and SCLC are the cancer types where SLC25A40 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.856	0.753	<.001	46	view →
LGG	OS	Median	All	0.369	0.520	<.001	39	view →
SCLC	DFS	Tertile	All	0.446	0.737	.005	38	view →
SKCM	DFS	Tertile	All	0.672	0.504	.001	37	view →
UCS	OS	Tertile	IV	1.000	0.206	.024	30	view →
LIHC	DFS	Quartile	All	0.406	0.617	<.001	29	view →
CESC	DFS	Median	III,IV	0.606	0.848	.006	28	view →
MESO	DFS	Quartile	All	0.149	0.786	.006	27	view →
ACC	DFS	Quartile	All	0.495	0.859	.001	25	view →
BRCA	DFS	Quartile	III,IV	0.935	0.787	.008	21	view →
THCA	OS	Median	II,III,IV	0.730	0.896	.004	21	view →
STAD	DFS	Quartile	IV	0.132	0.765	.001	20	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

SLC25A40–KIRC (OS)

Open the KIRC breakdown →