SLC25A39

Across TCGA pan-cancer cohorts, SLC25A39 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated SLC25A39 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLC25A39 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC25A39 expression acts as an unfavorable survival marker, although some lineages such as ESCA and OV show a favorable association.

KIRC, ACC, and HNSC are the cancer types where SLC25A39 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.833	0.930	<.001	146	view →
ACC	DFS	Median	All	0.216	0.723	<.001	124	view →
HNSC	DFS	Median	All	0.615	0.773	<.001	98	view →
LIHC	OS	Median	All	0.579	0.785	<.001	83	view →
SKCM	OS	Median	All	0.245	0.423	<.001	52	view →
LGG	DFS	Median	All	0.634	0.838	<.001	50	view →
UCS	OS	Median	II,III,IV	0.442	0.736	.009	48	view →
MESO	DFS	Median	III,IV	0.172	0.658	.001	45	view →
BLCA	DFS	Quartile	IV	0.165	0.683	.001	37	view →
SARC	OS	Quartile	All	0.642	0.846	.002	20	view →
CESC	DFS	Median	All	0.768	0.872	.013	18	view →
ESCA	DFS	Median	IV	0.704	0.249	.013	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

SLC25A39–KIRC (OS)

Open the KIRC breakdown →