SLC25A35

Across TCGA cell cohorts, SLC25A35 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC25A35-associated genes across cancer lineages are SLAMF1, GJD2, and FAM205A. Each is linked with SLC25A35 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A35-to-partner and partner-to-SLC25A35 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLAMF1 grouped by SLC25A35-low versus SLC25A35-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A35→partner) and Y-score (partner→SLC25A35) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLAMF1 →	+0.061	+3.333	<.001	.009	3	1
LARGE_INTESTINE	GJD2 →	+0.002	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FAM205A →	+0.018	+3.614	<.001	.006	3	1
OVARY	PNLIPRP1 →	+0.029	+4.450	<.001	.004	3	1
OVARY	OR2AK2 →	+0.073	+4.029	<.001	.009	3	1
OVARY	C1orf146 →	+0.032	+4.450	.003	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SLAMF1 by SLC25A35 expression — LARGE_INTESTINE

Explore this box plot interactively →