SLC25A31

Across TCGA pan-cancer cohorts, SLC25A31 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SLC25A31 data layer compared with 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SLC25A31 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SLC25A31 expression acts as an unfavorable survival marker, although some lineages such as ESCA and READ show a favorable association.

HNSC, OV, and ESCA are the cancer types where SLC25A31 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.160	0.410	.002	62	view →
OV	DFS	Quartile	All	0.102	0.183	<.001	60	view →
ESCA	DFS	Tertile	III,IV	0.641	0.298	.002	40	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
LIHC	DFS	Tertile	All	0.379	0.567	<.001	36	view →
KIRC	DFS	Quartile	All	0.702	0.843	.002	33	view →
MESO	OS	Tertile	IV	0.077	0.592	.019	27	view →
DLBC	OS	Tertile	III,IV	0.175	0.874	.025	27	view →
LGG	DFS	Median	All	0.307	0.448	<.001	26	view →
SCLC	DFS	Tertile	III,IV	0.137	0.756	.025	21	view →
UVM	DFS	Tertile	All	0.255	0.598	.037	18	view →
READ	OS	Tertile	III,IV	0.842	0.402	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SLC25A31–HNSC (OS)

Open the HNSC breakdown →