SLC25A31

Across TCGA pan-cancer cohorts, SLC25A31 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of SLC25A31’s most consistent transcriptional readouts.

The strongest signal is observed in cholangiocarcinoma (CHOL), where SLC25A31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC25A31 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

CHOL, COAD, and KICH are the cancer types where SLC25A31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CHOL	All	II,III,IV	+0.055	.008	4	view →
COAD	Female	All	+0.031	.036	4	view →
KICH	Female	All	−0.037	.017	3	view →
UCEC	All	All	+0.067	.031	2	view →
HNSC	All	III,IV	+0.020	.038	2	view →
LIHC	Male	II,III,IV	−0.019	.027	2	view →
LUSC	Male	II,III,IV	−0.026	.027	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

SLC25A31–CHOL

Open the CHOL breakdown →