SLC25A27

Across TCGA patient cohorts, SLC25A27 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A27-associated genes across cancer lineages are ATM, A-Raf_pS299, and ACVRL1. Each is linked with SLC25A27 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A27-to-partner and partner-to-SLC25A27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SLC25A27-low versus SLC25A27-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A27→partner) and Y-score (partner→SLC25A27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.609	-2.115	.002	.019	3	2
UCEC	A-Raf_pS299 →	-0.164	-3.459	.001	.005	3	1
UCEC	ACVRL1 →	-0.143	-2.439	.016	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.196	-2.102	.007	.019	3	1
UCEC	JNK2 →	+0.199	+2.115	.022	.019	3	1
UCEC	Ku80 →	+0.252	+2.128	.014	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by SLC25A27 expression — UCEC

Explore this box plot interactively →