SLC25A27

Across TCGA pan-cancer cohorts, SLC25A27 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLC25A27’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SLC25A27 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC25A27 is over-expressed in tumor, although a few such as LUAD and BLCA show the opposite, repressed pattern.

LUAD, BLCA, and LUSC are the cancer types where SLC25A27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	II,III,IV	−0.882	<.001	9	view →
BLCA	All	IV	−1.637	<.001	8	view →
LUSC	All	II,III,IV	−1.017	<.001	8	view →
COAD	Male	All	+0.996	<.001	7	view →
BRCA	All	III,IV	−2.143	<.001	6	view →
UCEC	All	All	−0.856	.001	6	view →
KICH	All	All	−0.889	.001	3	view →
THCA	All	II,III,IV	−0.565	.016	3	view →
READ	Female	All	+1.258	.008	2	view →
PRAD	All	All	+0.451	.010	2	view →
ESCA	Female	All	−1.490	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SLC25A27–LUAD

Open the LUAD breakdown →