SLC25A27

Across TCGA cell cohorts, SLC25A27 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC25A27-associated genes across cancer lineages are KIR2DL3, CLRN2, and ITGAD. Each is linked with SLC25A27 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A27-to-partner and partner-to-SLC25A27 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KIR2DL3 grouped by SLC25A27-low versus SLC25A27-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A27→partner) and Y-score (partner→SLC25A27) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
SKIN	CLRN2 →	+0.025	+4.977	<.001	.007	3	1
LARGE_INTESTINE	ITGAD →	+0.014	+4.510	<.001	.001	3	1
LARGE_INTESTINE	ACSM6 →	+0.031	+4.584	<.001	<.001	3	1
LARGE_INTESTINE	CFHR2 →	+0.046	+4.437	<.001	.004	3	1
BLOOD_Lymphoma	HTR3D →	+0.020	+6.247	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

KIR2DL3 by SLC25A27 expression — SKIN

Explore this box plot interactively →