SLC25A22

Across TCGA patient cohorts, SLC25A22 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A22-associated genes across cancer lineages are H3P46, VDAC2P4, and PPEF1-AS1. Each is linked with SLC25A22 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A22-to-partner and partner-to-SLC25A22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3P46 grouped by SLC25A22-low versus SLC25A22-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A22→partner) and Y-score (partner→SLC25A22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	H3P46 →	+0.193	+7.731	<.001	.009	3	1
CESC	VDAC2P4 →	+0.106	+5.010	<.001	.009	3	1
CESC	PPEF1-AS1 →	+0.116	+5.669	<.001	.003	3	1
CESC	LINC02222 →	+0.052	+6.837	<.001	<.001	3	1
CESC	MIR4510 →	+0.400	+6.342	<.001	.001	3	1
CESC	TBC1D3H →	+0.018	+5.418	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

H3P46 by SLC25A22 expression — BRCA

Explore this box plot interactively →