SLC25A20

Across TCGA pan-cancer cohorts, SLC25A20 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SLC25A20’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC25A20 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC25A20 is over-expressed in tumor, although a few such as COAD and KIRP show the opposite, repressed pattern.

COAD, KIRP, and KICH are the cancer types where SLC25A20 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC25A20 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.673	<.001	12	view →
KIRP	Male	III,IV	−0.902	<.001	11	view →
KICH	Male	II,III,IV	−1.699	<.001	10	view →
THCA	All	IV	−1.310	<.001	10	view →
LUAD	Female	II,III,IV	−0.786	<.001	9	view →
HNSC	Male	All	−0.671	<.001	9	view →
KIRC	Male	All	−0.518	<.001	9	view →
LUSC	Female	II,III,IV	−1.511	<.001	8	view →
BRCA	All	All	−0.696	<.001	8	view →
READ	All	All	−1.197	<.001	7	view →
UCEC	All	All	−0.701	<.001	6	view →
LIHC	All	All	−0.382	.004	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SLC25A20–COAD

Open the COAD breakdown →