SLC25A17

Across TCGA patient cohorts, SLC25A17 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC25A17-associated genes across cancer lineages are MEK1, ACC1, and Snail. Each is linked with SLC25A17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A17-to-partner and partner-to-SLC25A17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by SLC25A17-low versus SLC25A17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A17→partner) and Y-score (partner→SLC25A17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.506	+3.700	.002	.001	3	2
SKCM	ACC1 →	+0.387	+3.000	.029	.036	3	1
SKCM	Snail →	-0.229	-3.000	.019	.036	3	1
SKCM	Src →	-0.293	-3.000	.026	.036	3	1
UCEC	EGFR_pY1068 →	-0.236	-3.000	.043	.036	3	1
UCEC	eIF4E →	+0.214	+2.820	.029	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

MEK1 by SLC25A17 expression — UCEC

Explore this box plot interactively →