SLC25A17

Across TCGA pan-cancer cohorts, SLC25A17 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated SLC25A17 data layer compared with 5 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SLC25A17 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SLC25A17 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LUSC show a favorable association.

UVM, ACC, and KIRP are the cancer types where SLC25A17 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	All	0.294	0.835	.001	86	view →
ACC	DFS	Median	All	0.225	0.656	<.001	80	view →
KIRP	DFS	Median	IV	0.036	0.528	.001	70	view →
LIHC	DFS	Median	All	0.467	0.612	<.001	59	view →
HNSC	OS	Median	All	0.281	0.519	.001	56	view →
KIRC	OS	Quartile	All	0.686	0.472	<.001	45	view →
LUSC	OS	Median	All	0.807	0.714	.013	38	view →
READ	DFS	Quartile	II,III,IV	0.661	0.282	.007	33	view →
THYM	DFS	Quartile	II,III,IV	1.000	0.607	.003	28	view →
SARC	OS	Tertile	All	0.432	0.649	<.001	24	view →
SCLC	OS	Median	III,IV	0.789	0.455	.010	17	view →
CHOL	OS	Quartile	All	0.336	0.861	.002	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

SLC25A17–UVM (DFS)

Open the UVM breakdown →