SLC25A12

Across TCGA cell cohorts, SLC25A12 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC25A12-associated genes across cancer lineages are PDCL2, REG1B, and SMIM33. Each is linked with SLC25A12 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC25A12-to-partner and partner-to-SLC25A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCL2 grouped by SLC25A12-low versus SLC25A12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC25A12→partner) and Y-score (partner→SLC25A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PDCL2 →	+0.165	+3.584	.002	.003	3	1
LARGE_INTESTINE	REG1B →	+2.588	+2.518	<.001	.006	3	1
LARGE_INTESTINE	SMIM33 →	+0.602	+2.577	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.024	+3.415	<.001	.001	3	1
LARGE_INTESTINE	NEXMIF →	+0.188	+2.518	<.001	.006	3	1
SKIN	AVPR1B →	+0.013	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PDCL2 by SLC25A12 expression — LARGE_INTESTINE

Explore this box plot interactively →