SLC24A4

Across TCGA patient cohorts, SLC24A4 mutation is significantly associated with the RNA expression of many other genes, with 2,864 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC24A4-associated genes across cancer lineages are PFKFB4, PITPNB, and ADNP2. Each is linked with SLC24A4 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC24A4-to-partner and partner-to-SLC24A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PFKFB4 grouped by SLC24A4-low versus SLC24A4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC24A4→partner) and Y-score (partner→SLC24A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	PFKFB4 →	+1.053	+3.207	.004	.009	3	5
UCEC	PITPNB →	+0.345	+1.809	.002	.001	3	4
UCEC	ADNP2 →	+0.511	+1.805	<.001	.007	3	4
UCEC	YWHAE →	+0.327	+2.117	.001	<.001	3	4
LUAD	RFC5 →	+0.693	+3.205	<.001	.009	3	4
UCEC	PDS5A →	+0.461	+2.047	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,864 associations by consensus.

PFKFB4 by SLC24A4 expression — SKCM

Explore this box plot interactively →