SLC24A4

Across TCGA patient cohorts, SLC24A4 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC24A4-associated genes across cancer lineages are PCNA, Caspase-7-cleavedD198, and PDCD4. Each is linked with SLC24A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC24A4-to-partner and partner-to-SLC24A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by SLC24A4-low versus SLC24A4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC24A4→partner) and Y-score (partner→SLC24A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PCNA →	+0.263	+3.008	.041	.019	3	4
STAD	Caspase-7-cleavedD198 →	+1.160	+3.169	.001	.018	3	3
UCEC	PDCD4 →	-0.471	-1.440	.003	.024	3	3
UCEC	4E-BP1_pT37_T46 →	-0.262	-1.687	.043	.040	3	3
UCEC	C-Raf →	+0.217	+2.321	<.001	.005	3	3
COAD	ATM →	-0.562	-2.991	.005	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by SLC24A4 expression — COAD

Explore this box plot interactively →