SLC24A4

Across TCGA cell cohorts, SLC24A4 mutation is significantly associated with the RNA expression of many other genes, with 22 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SLC24A4-associated genes across cancer lineages are H2BC1, H2AC1, and KRTAP10-1. Each is linked with SLC24A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC24A4-to-partner and partner-to-SLC24A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2BC1 grouped by SLC24A4-low versus SLC24A4-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC24A4→partner) and Y-score (partner→SLC24A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	H2BC1 →	+0.433	+5.977	<.001	.001	3	1
SOFT_TISSUE	H2AC1 →	+0.193	+5.977	<.001	.001	3	1
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	1
SOFT_TISSUE	GAGE12E →	+0.090	+4.930	<.001	.008	3	1
CNS	ZC2HC1B →	+0.028	+3.584	<.001	.003	3	1
CNS	TBATA →	+0.011	+4.357	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

H2BC1 by SLC24A4 expression — SOFT_TISSUE

Explore this box plot interactively →