SLC23A2

Across TCGA patient cohorts, SLC23A2 mutation is significantly associated with the total protein of many other genes, with 50 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC23A2-associated genes across cancer lineages are Caspase-7-cleavedD198, MEK1, and EGFR_pY1068. Each is linked with SLC23A2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC23A2-to-partner and partner-to-SLC23A2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SLC23A2-low versus SLC23A2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC23A2→partner) and Y-score (partner→SLC23A2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.228	+3.330	<.001	.005	2	3
COAD	MEK1 →	+0.251	+2.824	.007	.034	3	2
UCEC	EGFR_pY1068 →	-0.290	-2.485	<.001	<.001	3	2
UCEC	A-Raf_pS299 →	-0.107	-3.000	.004	<.001	3	2
UCEC	ERK2 →	+0.140	+1.415	.018	.040	3	2
UCEC	FoxM1 →	+0.208	+2.169	.009	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

Caspase-7-cleavedD198 by SLC23A2 expression — COAD

Explore this box plot interactively →