SLC23A2

Across TCGA pan-cancer cohorts, SLC23A2 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SLC23A2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC23A2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC23A2 is over-expressed in tumor, although a few such as THCA and UCEC show the opposite, repressed pattern.

HNSC, THCA, and UCEC are the cancer types where SLC23A2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC23A2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.963	<.001	12	view →
THCA	Male	All	−0.807	<.001	9	view →
UCEC	All	All	−1.688	<.001	8	view →
BRCA	Female	All	−0.689	<.001	6	view →
KICH	All	All	−0.648	<.001	6	view →
LUAD	All	All	−0.392	.001	5	view →
READ	All	III,IV	+0.549	.010	2	view →
ESCA	All	All	+0.651	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SLC23A2–HNSC

Open the HNSC breakdown →