SLC22A8

Across TCGA patient cohorts, SLC22A8 mutation is significantly associated with the RNA expression of many other genes, with 2,659 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A8-associated genes across cancer lineages are FAF1, CIDECP1, and E2F1. Each is linked with SLC22A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A8-to-partner and partner-to-SLC22A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAF1 grouped by SLC22A8-low versus SLC22A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A8→partner) and Y-score (partner→SLC22A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAF1 →	+0.255	+2.243	.005	.005	3	3
UCEC	CIDECP1 →	+0.340	+2.748	<.001	<.001	3	3
UCEC	E2F1 →	+0.597	+2.861	.005	.001	3	3
UCEC	CHAF1A →	+0.579	+2.136	<.001	<.001	3	3
UCEC	ACBD5 →	+0.437	+1.836	.003	.001	3	3
UCEC	UFM1 →	+0.460	+1.606	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,659 associations by consensus.

FAF1 by SLC22A8 expression — UCEC

Explore this box plot interactively →