SLC22A8

Across TCGA pan-cancer cohorts, SLC22A8 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated SLC22A8 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher SLC22A8 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC22A8 expression acts as an unfavorable survival marker, although some lineages such as KIRC and HNSC show a favorable association.

KIRC, UCEC, and DLBC are the cancer types where SLC22A8 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.740	0.505	<.001	141	view →
UCEC	DFS	Quartile	All	0.461	0.694	.004	56	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	47	view →
BRCA	DFS	Tertile	All	0.570	1.000	.033	36	view →
MESO	OS	Tertile	All	0.146	0.584	.002	27	view →
LIHC	OS	Quartile	All	0.660	0.820	.001	21	view →
THYM	OS	Tertile	All	0.603	0.935	.004	20	view →
SCLC	DFS	Tertile	All	0.192	0.793	.017	18	view →
HNSC	OS	Median	IV	0.736	0.568	.005	17	view →
LGG	OS	Median	All	0.547	0.366	<.001	14	view →
COAD	OS	Tertile	III,IV	0.440	0.813	.004	12	view →
STAD	OS	Median	III,IV	0.554	0.676	.032	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

SLC22A8–KIRC (DFS)

Open the KIRC breakdown →