SLC22A8

Across TCGA patient cohorts, SLC22A8 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A8-associated genes across cancer lineages are p27_pT198, p70-S6K_pT389, and PCNA. Each is linked with SLC22A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A8-to-partner and partner-to-SLC22A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p27_pT198 grouped by SLC22A8-low versus SLC22A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A8→partner) and Y-score (partner→SLC22A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p27_pT198 →	+0.114	+2.700	.002	.006	3	2
UCEC	p70-S6K_pT389 →	-0.154	-2.459	.022	.018	3	2
UCEC	PCNA →	+0.250	+2.874	.001	<.001	3	2
UCEC	Annexin-1 →	+0.549	+2.604	.003	.005	3	2
UCEC	S6_pS240_S244 →	+0.403	+2.392	.004	<.001	3	2
UCEC	ASNS →	+0.338	+1.584	.008	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

p27_pT198 by SLC22A8 expression — UCEC

Explore this box plot interactively →