SLC22A8

Across TCGA cell cohorts, SLC22A8 RNA expression is significantly associated with the mutation status of many other genes, with 93 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SLC22A8-associated genes across cancer lineages are PTPRM, OGFRL1, and FBXW9. Each is linked with SLC22A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A8-to-partner and partner-to-SLC22A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRM grouped by SLC22A8-low versus SLC22A8-high in LARGE_INTESTINE.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A8→partner) and Y-score (partner→SLC22A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PTPRM →	+1.495	+0.012	.006	.009	3	2
LUNG_NSCLC_LUAD	OGFRL1 →	+3.628	+0.021	.002	<.001	3	2
LUNG_NSCLC_LUAD	FBXW9 →	+3.628	+0.016	.002	.002	3	2
LUNG_SCLC	L1TD1 →	+4.044	+0.877	.009	<.001	3	2
CNS	ARHGAP11A →	+3.459	+0.904	.006	<.001	3	2
LIVER	CACNA2D4 →	+3.662	+0.595	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

PTPRM by SLC22A8 expression — LARGE_INTESTINE

Explore this box plot interactively →