SLC22A8

Across TCGA cell cohorts, SLC22A8 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SLC22A8-associated genes across cancer lineages are MAGEB4, SLC22A2, and ZP4. Each is linked with SLC22A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A8-to-partner and partner-to-SLC22A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by SLC22A8-low versus SLC22A8-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A8→partner) and Y-score (partner→SLC22A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MAGEB4 →	+1.044	+4.459	<.001	.001	3	2
BLOOD_Lymphoma	SLC22A2 →	+0.252	+4.025	<.001	.004	3	1
BLOOD_Lymphoma	ZP4 →	+0.354	+4.321	.002	.002	3	1
BLOOD_Lymphoma	CST11 →	+0.880	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	ANKRD33 →	+0.003	+4.058	<.001	.009	3	1
BLOOD_Lymphoma	GRM5 →	+0.452	+3.927	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MAGEB4 by SLC22A8 expression — BLOOD_Lymphoma

Explore this box plot interactively →