Across TCGA cell cohorts, SLC22A6 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A6-associated genes across cancer lineages are HHLA1, CT45A2, and LILRB1. Each is linked with SLC22A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A6-to-partner and partner-to-SLC22A6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A6→partner) and Y-score (partner→SLC22A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HHLA1 →	+0.009	+3.551	<.001	.009	3	1
BLOOD_Leukemia	CT45A2 →	+1.339	+4.234	<.001	.003	3	1
SKIN	LILRB1 →	+0.050	+3.736	<.001	.007	3	1
SKIN	IFNG →	+0.011	+3.700	<.001	.009	3	1
OVARY	OR2AK2 →	+0.062	+4.029	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.010	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

SLC22A6 survival (RNA) · tumor vs normal (RNA) · all SLC22A6 data types