Across TCGA patient cohorts, SLC22A4 mutation is significantly associated with the RNA expression of many other genes, with 1,935 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A4-associated genes across cancer lineages are RN7SL248P, RNA5SP282, and RNU6-964P. Each is linked with SLC22A4 in more than 3 cancer types. Because this analysis shows association rather than direction, both SLC22A4-to-partner and partner-to-SLC22A4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A4→partner) and Y-score (partner→SLC22A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.007	3	4
SKCM	RNA5SP282 →	+0.535	+5.075	<.001	.001	3	2
SKCM	RNU6-964P →	+0.680	+4.215	<.001	.009	3	2
LUAD	ELOA3P →	+0.053	+5.315	<.001	.003	3	2
LUSC	RNU6-1306P →	+0.454	+4.236	.001	.008	3	2
COAD	RPL31P20 →	+0.334	+5.145	.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,935 associations by consensus.

Exploration

SLC22A4 survival (RNA) · tumor vs normal (RNA) · all SLC22A4 data types