Across TCGA cell cohorts, SLC22A25 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A25-associated genes across cancer lineages are LALBA, DEFB108B, and OR8D2. Each is linked with SLC22A25 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A25-to-partner and partner-to-SLC22A25 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A25→partner) and Y-score (partner→SLC22A25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LALBA →	+0.023	+3.345	<.001	.001	3	2
LUNG_NSCLC_LUAD	DEFB108B →	+0.167	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR8D2 →	+0.065	+4.371	<.001	.005	3	1
LUNG_SCLC	OR52E4 →	+0.107	+3.925	.003	.004	3	1
LUNG_SCLC	GPR141 →	+0.388	+3.662	.003	.009	3	1
LUNG_SCLC	OR11G2 →	+0.018	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Exploration

SLC22A25 survival (RNA) · tumor vs normal (RNA) · all SLC22A25 data types