SLC22A23

Across TCGA cell cohorts, SLC22A23 mutation is significantly associated with the mutation status of many other genes, with 4,055 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A23-associated genes across cancer lineages are TCF20, CPSF7, and UNC5D. Each is linked with SLC22A23 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC22A23-to-partner and partner-to-SLC22A23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF20 grouped by SLC22A23-low versus SLC22A23-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A23→partner) and Y-score (partner→SLC22A23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TCF20 →	+1.807	+4.000	<.001	<.001	1	5
BLOOD_Lymphoma	CPSF7 →	+4.584	+4.584	.007	.007	1	4
BLOOD_Leukemia	UNC5D →	+4.000	+5.050	.008	.008	1	4
SKIN	IQGAP2 →	+3.053	+4.662	<.001	<.001	1	4
SKIN	PTPRK →	+2.468	+4.169	.003	.003	1	4
SKIN	ADARB2 →	+3.053	+3.718	.006	.006	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,055 associations by consensus.

TCF20 by SLC22A23 expression — LARGE_INTESTINE

Explore this box plot interactively →