SLC22A18AS

Across TCGA pan-cancer cohorts, SLC22A18AS RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SLC22A18AS’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SLC22A18AS RNA is repressed in tumor relative to normal tissue. In most cancer types SLC22A18AS is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, HNSC, and LUAD are the cancer types where SLC22A18AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC22A18AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−2.254	<.001	11	view →
HNSC	All	III,IV	+0.765	<.001	11	view →
LUAD	Female	II,III,IV	+1.898	<.001	9	view →
KICH	Male	II,III,IV	−1.955	<.001	8	view →
READ	All	All	−2.445	<.001	7	view →
THCA	All	II,III,IV	+0.765	<.001	7	view →
LIHC	Male	All	+0.619	.019	3	view →
LUSC	All	All	+0.359	.001	3	view →
PAAD	All	All	+1.599	.007	2	view →
KIRP	All	III,IV	−1.060	.024	2	view →
PRAD	All	All	−0.379	<.001	2	view →
BRCA	All	II,III,IV	−0.198	.023	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SLC22A18AS–COAD

Open the COAD breakdown →