SLC22A16

Across TCGA patient cohorts, SLC22A16 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A16-associated genes across cancer lineages are C-Raf, Caspase-7-cleavedD198, and VHL. Each is linked with SLC22A16 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A16-to-partner and partner-to-SLC22A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by SLC22A16-low versus SLC22A16-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A16→partner) and Y-score (partner→SLC22A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	C-Raf →	+0.110	+3.025	.031	.018	3	3
UCEC	Caspase-7-cleavedD198 →	+0.759	+3.479	.003	.002	3	3
UCEC	VHL →	-1.202	-2.807	<.001	.003	3	2
UCEC	Di-Ras3 →	-0.166	-2.986	.010	.035	3	2
LUAD	LNC2_active →	-0.892	-3.308	.033	.009	3	1
LUAD	LKB1 →	+0.159	+3.169	.004	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

C-Raf by SLC22A16 expression — LUAD

Explore this box plot interactively →