SLC22A16

Across TCGA cell cohorts, SLC22A16 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,520 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC22A16-associated GO terms across cancer lineages are Cellular response to reactive oxygen species, Regulation of substrate adhesion-dependent cell spreading, and Actin filament depolymerization. Each is linked with SLC22A16 in more than 5 cancer types. Because this analysis shows association rather than direction, both SLC22A16-to-partner and partner-to-SLC22A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to reactive oxygen species grouped by SLC22A16-low versus SLC22A16-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A16→partner) and Y-score (partner→SLC22A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Cellular response to reactive oxygen species →	+0.034	+0.031	.006	.002	3	6
LARGE_INTESTINE	Regulation of substrate adhesion-dependent cell spreading →	+0.070	+0.058	.001	.007	3	6
LUNG_NSCLC_LUAD	Actin filament depolymerization →	+0.088	+0.032	.002	.001	3	5
PANCREAS	Cellular response to oxidative stress →	+0.055	+0.048	<.001	.007	3	4
CNS	Positive regulation of transforming growth factor beta production →	+0.111	+0.057	.004	.001	2	5
CNS	Protein polyubiquitination →	+0.028	+0.043	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,520 associations by consensus.

Cellular response to reactive oxygen species by SLC22A16 expression — PANCREAS

Explore this box plot interactively →