SLC22A16

Across TCGA cell cohorts, SLC22A16 mutation is significantly associated with the RNA expression of many other genes, with 287 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC22A16-associated genes across cancer lineages are CYP11B1, AQP12A, and IFNA4. Each is linked with SLC22A16 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A16-to-partner and partner-to-SLC22A16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP11B1 grouped by SLC22A16-low versus SLC22A16-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A16→partner) and Y-score (partner→SLC22A16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	CYP11B1 →	+0.012	+4.981	<.001	.008	3	1
CNS	AQP12A →	+0.047	+4.981	<.001	.008	3	1
CNS	IFNA4 →	+0.215	+5.321	<.001	.005	3	1
LARGE_INTESTINE	FATE1 →	+0.034	+3.196	.006	.007	3	1
LARGE_INTESTINE	FOLR2 →	+0.058	+3.716	.004	.008	3	1
LARGE_INTESTINE	UTF1 →	+0.020	+3.632	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 287 associations by consensus.

CYP11B1 by SLC22A16 expression — CNS

Explore this box plot interactively →