SLC22A14

Across TCGA pan-cancer cohorts, SLC22A14 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SLC22A14 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SLC22A14 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated SLC22A14 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, THCA, and PRAD are the cancer types where SLC22A14 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.890	.018	22	view →
THCA	OS	Median	All	0.294	0.945	<.001	8	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUAD	DFS	Median	II,III,IV	0.098	0.682	<.001	6	view →
HNSC	DFS	Median	IV	0.160	0.581	.041	5	view →
BRCA	OS	Median	II,III,IV	0.602	0.958	.017	4	view →
SKCM	DFS	Median	All	0.576	0.740	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SLC22A14–UCEC (DFS)

Open the UCEC breakdown →