SLC22A14

Across TCGA pan-cancer cohorts, SLC22A14 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SLC22A14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SLC22A14 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC22A14 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, UCEC, and LUSC are the cancer types where SLC22A14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC22A14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	All	−0.197	<.001	9	view →
UCEC	All	All	+0.184	.003	6	view →
LUSC	Male	All	+0.122	<.001	6	view →
THCA	Male	All	−0.048	.001	4	view →
COAD	All	All	+0.061	.032	3	view →
CHOL	Female	All	+0.210	.005	2	view →
LUAD	Female	All	+0.065	.028	2	view →
KIRC	Female	All	+0.199	.022	1	view →
KIRP	All	II,III,IV	−0.182	.044	1	view →
COAD	Male	IV	−0.032	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 9 lineages.

SLC22A14–KICH

Open the KICH breakdown →