SLC22A14

Across TCGA patient cohorts, SLC22A14 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A14-associated genes across cancer lineages are PDCD4, 4E-BP1_pT70, and 4E-BP1. Each is linked with SLC22A14 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A14-to-partner and partner-to-SLC22A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by SLC22A14-low versus SLC22A14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A14→partner) and Y-score (partner→SLC22A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.573	-2.087	.001	.005	3	2
COAD	4E-BP1_pT70 →	+0.181	+3.178	.002	.010	3	2
UCEC	4E-BP1 →	+0.413	+3.584	<.001	.002	3	2
UCEC	Caspase-8 →	-0.246	-3.673	.010	.001	3	2
UCEC	eEF2 →	+0.269	+2.999	.049	.035	3	2
UCEC	EGFR_pY1173 →	+0.081	+2.999	.008	.035	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

PDCD4 by SLC22A14 expression — UCEC

Explore this box plot interactively →