SLC22A14

Across TCGA cell cohorts, SLC22A14 mutation is significantly associated with the mutation status of many other genes, with 5,943 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A14-associated genes across cancer lineages are MLH3, PRRC2A, and KMT2A. Each is linked with SLC22A14 in more than 4 cancer types. Because this analysis shows association rather than direction, both SLC22A14-to-partner and partner-to-SLC22A14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MLH3 grouped by SLC22A14-low versus SLC22A14-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A14→partner) and Y-score (partner→SLC22A14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MLH3 →	+2.870	+3.347	.009	.009	1	5
LARGE_INTESTINE	PRRC2A →	+1.999	+2.584	<.001	<.001	1	5
SKIN	KMT2A →	+2.736	+2.963	.004	.004	1	5
BLOOD_Leukemia	ADAMTS19 →	+3.548	+3.845	.003	.003	1	4
BLOOD_Leukemia	CNTN5 →	+2.870	+3.347	.009	.009	1	4
SKIN	SACS →	+2.473	+3.139	.002	.002	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,943 associations by consensus.

MLH3 by SLC22A14 expression — BLOOD_Leukemia

Explore this box plot interactively →