SLC22A1

Across TCGA patient cohorts, SLC22A1 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,092 significant associations in total. OV shows the largest number of these associations.

The most reproducible SLC22A1-associated GO terms across cancer lineages are Metanephric proximal tubule development, High-density lipoprotein particle assembly, and Regulation of transcription of nucleolar large rRNA by RNA polymerase I. Each is linked with SLC22A1 in more than 19 cancer types. Because this analysis shows association rather than direction, both SLC22A1-to-partner and partner-to-SLC22A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Metanephric proximal tubule development grouped by SLC22A1-low versus SLC22A1-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A1→partner) and Y-score (partner→SLC22A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Metanephric proximal tubule development →	-0.092	-0.597	<.001	<.001	3	20
CHOL	High-density lipoprotein particle assembly →	+0.135	+4.328	<.001	<.001	3	16
LUSC	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.054	+0.443	<.001	<.001	3	15
STAD	Regulation of post-translational protein modification →	+0.046	+0.212	<.001	<.001	3	15
STAD	Positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage →	+0.067	+0.250	<.001	.002	2	16
STAD	Nuclear export →	+0.047	+0.240	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,092 associations by consensus.

Metanephric proximal tubule development by SLC22A1 expression — ESCA

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