SLC22A1

Across TCGA pan-cancer cohorts, SLC22A1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SLC22A1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SLC22A1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SLC22A1 is over-expressed in tumor, although a few such as KICH and LIHC show the opposite, repressed pattern.

HNSC, KICH, and LIHC are the cancer types where SLC22A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC22A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.944	<.001	12	view →
KICH	Female	All	−0.904	<.001	9	view →
LIHC	Female	II,III,IV	−4.980	<.001	8	view →
KIRP	All	III,IV	−1.012	<.001	8	view →
THCA	All	All	−0.174	.001	7	view →
UCEC	All	All	+0.305	.039	6	view →
CHOL	Female	All	−8.436	<.001	5	view →
KIRC	All	All	−0.397	<.001	5	view →
STAD	Male	All	+0.290	<.001	4	view →
COAD	All	All	+0.130	.017	4	view →
LUSC	All	All	+0.336	.010	3	view →
READ	All	All	+0.358	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SLC22A1–HNSC

Open the HNSC breakdown →