SLC22A1

Across TCGA patient cohorts, SLC22A1 mutation is significantly associated with the RNA expression of many other genes, with 3,681 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SLC22A1-associated genes across cancer lineages are TRIAP1P1, RBM22P7, and RNA5SP182. Each is linked with SLC22A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SLC22A1-to-partner and partner-to-SLC22A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIAP1P1 grouped by SLC22A1-low versus SLC22A1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A1→partner) and Y-score (partner→SLC22A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	TRIAP1P1 →	+0.170	+5.321	<.001	.002	3	3
BRCA	RBM22P7 →	+0.109	+9.057	<.001	.003	3	2
BRCA	RNA5SP182 →	+1.228	+9.057	<.001	.003	3	2
UCEC	KIT →	-0.690	-1.874	<.001	<.001	3	2
UCEC	HCN2 →	+0.378	+1.526	.001	.001	3	2
UCEC	ARRDC3-AS1 →	+0.189	+2.396	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,681 associations by consensus.

TRIAP1P1 by SLC22A1 expression — LUSC

Explore this box plot interactively →