SLC22A1

Across TCGA cell cohorts, SLC22A1 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SLC22A1-associated genes across cancer lineages are NLRP8, KLHL34, and PPIAL4F. Each is linked with SLC22A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC22A1-to-partner and partner-to-SLC22A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NLRP8 grouped by SLC22A1-low versus SLC22A1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC22A1→partner) and Y-score (partner→SLC22A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	PPIAL4F →	+0.060	+4.906	<.001	.006	3	1
BLOOD_Leukemia	CRYAA →	+0.091	+4.705	<.001	.003	3	1
BLOOD_Leukemia	PRM3 →	+0.067	+5.569	<.001	.001	3	1
BLOOD_Leukemia	DEFB125 →	+0.036	+5.060	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

NLRP8 by SLC22A1 expression — OESOPHAGUS

Explore this box plot interactively →