SLC1A5

Across TCGA cell cohorts, SLC1A5 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SLC1A5-associated genes across cancer lineages are MAGEB4, WNT8A, and MMP27. Each is linked with SLC1A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SLC1A5-to-partner and partner-to-SLC1A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by SLC1A5-low versus SLC1A5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SLC1A5→partner) and Y-score (partner→SLC1A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.019	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	WNT8A →	+0.022	+4.217	.002	.001	3	1
BLOOD_Leukemia	MMP27 →	+0.019	+4.969	<.001	.003	3	1
BLOOD_Leukemia	SYCN →	+0.053	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.061	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TEX13C →	+0.043	+4.409	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MAGEB4 by SLC1A5 expression — LARGE_INTESTINE

Explore this box plot interactively →